USC-OGP 2-DE database Two-dimensional polyacrylamide gel electrophoresis database

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Searching in 'USC-OGP 2-DE database' for entry matching: P15531 USC-OGP 2-DE database:  P15531 P15531 General information about the entry View entry in simple text format Entry name NDKA_HUMAN Primary accession number P15531 integrated into USC-OGP 2-DE database on  January 17, 2017 (release 1) 2D Annotations were last modified on January 17, 2017 (version 1) General Annotations were last modified on  April 5, 2017 (version 2) Name and origin of the protein Description RecName: Full=Nucleoside diphosphate kinase A; Short=NDK A; Short=NDP kinase A; EC=2.7.4.6; AltName: Full=Granzyme A-activated DNase; Short=GAAD; AltName: Full=Metastasis inhibition factor nm23; AltName: Full=NM23-H1; AltName: Full=Tumor metastatic process-associated protein;. Gene name Name=NME1 Synonyms=NDPKA, NM23 Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION Author 1., Author 2. Submitted (Mar-2011) to Current 2D PAGE maps for identified proteins How to interpret a protein PLATELET_4-7 {PLATELET 4-7} Homo sapiens (Human)   map experimental info   PLATELET_4-7 MAP LOCATIONS: SPOT OGP-0573: pI=5.64; Mw=19276 UVEAL_MELANOMA_3-10 {UVEAL MELANOMA 3-10} Homo sapiens (Human)   map experimental info   UVEAL_MELANOMA_3-10 MAP LOCATIONS: SPOT OGP-1317: pI=5.84; Mw=19745 SPOT OGP-1320: pI=4.70; Mw=19395 Cross-references UniProtKB/Swiss-Prot P15531; NDKA_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name NDKA_HUMAN Primary accession number P15531 Secondary accession number(s) Q6FGK3 Q86XQ2 Q9UDJ6 Sequence was last modified on  April 1, 1990 (version 1) Annotations were last modified on  March 15, 2017 (version 198) Name and origin of the protein Description RecName: Full=Nucleoside diphosphate kinase A; Short=NDK A; Short=NDP kinase A; EC=2.7.4.6; AltName: Full=Granzyme A-activated DNase; Short=GAAD; AltName: Full=Metastasis inhibition factor nm23; AltName: Full=NM23-H1; AltName: Full=Tumor metastatic process-associated protein; Gene name Name=NME1 Synonyms=NDPKA, NM23 Encoded on Name=NME1; Synonyms=NDPKA, NM23 Keywords 3D-structure; Alternative splicing; ATP-binding; Complete proteome; Cytoplasm; Differentiation; Direct protein sequencing; Endocytosis; Isopeptide bond; Kinase; Magnesium; Metal-binding; Neurogenesis; Nucleotide metabolism; Nucleotide-binding; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Transferase; Ubl conjugation. Copyright Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL X17620; CAA35621.1; ALT_INIT; mRNA EMBL X73066; CAA51527.1; -; mRNA EMBL X75598; CAA53270.1; -; Genomic_DNA EMBL AF487339; AAO85436.1; -; mRNA EMBL AK291105; BAF83794.1; -; mRNA EMBL CR542104; CAG46901.1; -; mRNA EMBL CR542115; CAG46912.1; -; mRNA EMBL AC005839; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL CH471109; EAW94568.1; -; Genomic_DNA EMBL BC000293; AAH00293.1; -; mRNA EMBL BC018994; AAH18994.1; -; mRNA CCDS CCDS11578.1; -. [P15531-2]; . CCDS CCDS11579.1; -. [P15531-1]; . PIR A33386; A33386; . RefSeq NP_000260.1; NM_000269.2. [P15531-1]; . RefSeq NP_937818.1; NM_198175.1. [P15531-2]; . UniGene Hs.463456; -; . PDB 1JXV; X-ray; 2.20 A; A/B/C/D/E/F=1-152 PDB 1UCN; X-ray; 2.00 A; A/B/C=1-152 PDB 2HVD; X-ray; 2.15 A; A/B/C=1-152 PDB 2HVE; X-ray; 2.40 A; A/B/C=1-152 PDB 3L7U; X-ray; 2.10 A; A/B/C=1-152 PDB 4ENO; X-ray; 2.80 A; A/B=1-152 PDBsum 1JXV; -; . PDBsum 1UCN; -; . PDBsum 2HVD; -; . PDBsum 2HVE; -; . PDBsum 3L7U; -; . PDBsum 4ENO; -; . ProteinModelPortal P15531; -; . SMR P15531; -; . BioGrid 110894; 58; . DIP DIP-39164N; -; . IntAct P15531; 29; . MINT MINT-221462; -; . STRING 9606.ENSP00000013034; -; . ChEMBL CHEMBL2159; -; . DrugBank DB03491; 2'-Deoxyguanosine-5'-Diphosphate; . DrugBank DB02181; 2'-Deoxyguanosine-5'-Triphosphate; . DrugBank DB04542; 3'-Azido-3'-Deoxythymidine-5'-Diphosphate; . DrugBank DB04366; 3'-Deoxy 3'-Amino Adenosine-5'-Diphosphate; . DrugBank DB00718; Adefovir Dipivoxil; . DrugBank DB02607; Adenosine Phosphonoacetic Acid; . DrugBank DB04068; Fudp; . DrugBank DB04315; Guanosine-5'-Diphosphate; . DrugBank DB00709; Lamivudine; . DrugBank DB02345; Selenocysteine; . DrugBank DB00300; Tenofovir; . DrugBank DB03103; Thymidine-5'- Diphosphate; . iPTMnet P15531; -; . PhosphoSitePlus P15531; -; . SwissPalm P15531; -; . BioMuta NME1; -; . DMDM 127981; -; . DOSAC-COBS-2DPAGE P15531; -; . OGP P15531; -; . EPD P15531; -; . PaxDb P15531; -; . PeptideAtlas P15531; -; . PRIDE P15531; -; . TopDownProteomics P15531-1; -. [P15531-1]; . DNASU 4830; -; . Ensembl ENST00000013034; ENSP00000013034; ENSG00000239672. [P15531-2]; . Ensembl ENST00000336097; ENSP00000337060; ENSG00000239672. [P15531-2]; . Ensembl ENST00000393196; ENSP00000376892; ENSG00000239672. [P15531-1]; . GeneID 4830; -; . KEGG hsa:4830; -; . UCSC uc002ith.3; human. [P15531-1]; . CTD 4830; -; . DisGeNET 4830; -; . GeneCards NME1; -; . HGNC HGNC:7849; NME1; . HPA CAB040571; -; . HPA HPA008467; -; . HPA HPA041113; -; . MalaCards NME1; -; . MIM 156490; gene; . neXtProt NX_P15531; -; . OpenTargets ENSG00000239672; -; . PharmGKB PA249; -; . eggNOG KOG0888; Eukaryota; . eggNOG COG0105; LUCA; . GeneTree ENSGT00760000119146; -; . HOGENOM HOG000224564; -; . HOVERGEN HBG000423; -; . InParanoid P15531; -; . KO K00940; -; . OMA VERFFME; -; . OrthoDB EOG091G0PLD; -; . PhylomeDB P15531; -; . TreeFam TF106373; -; . BioCyc MetaCyc:ENSG00000011052-MONOMER; -; . BRENDA 2.7.4.6; 2681; . Reactome R-HSA-499943; Synthesis and interconversion of nucleotide di- and triphosphates; . SIGNOR P15531; -; . ChiTaRS NME1; human; . EvolutionaryTrace P15531; -; . GeneWiki NME1; -; . GenomeRNAi 4830; -; . PRO PR:P15531; -; . Proteomes UP000005640; Chromosome 17; . Bgee ENSG00000239672; -; . CleanEx HS_NME1; -; . ExpressionAtlas P15531; baseline and differential; . Genevisible P15531; HS; . GO GO:0005813; C:centrosome; IEA:Ensembl; . GO GO:0005737; C:cytoplasm; TAS:UniProtKB; . GO GO:0005829; C:cytosol; IDA:UniProtKB; . GO GO:0070062; C:extracellular exosome; IDA:UniProtKB; . GO GO:0005882; C:intermediate filament; IEA:Ensembl; . GO GO:0016020; C:membrane; IDA:UniProtKB; . GO GO:0005741; C:mitochondrial outer membrane; IEA:Ensembl; . GO GO:0043209; C:myelin sheath; IEA:Ensembl; . GO GO:0005634; C:nucleus; IDA:UniProtKB; . GO GO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl; . GO GO:0032587; C:ruffle membrane; IDA:UniProtKB; . GO GO:0005524; F:ATP binding; IDA:UniProtKB; . GO GO:0004536; F:deoxyribonuclease activity; IDA:UniProtKB; . GO GO:0005525; F:GTP binding; IDA:UniProtKB; . GO GO:0042802; F:identical protein binding; IPI:IntAct; . GO GO:0000287; F:magnesium ion binding; IDA:UniProtKB; . GO GO:0004550; F:nucleoside diphosphate kinase activity; IDA:UniProtKB; . GO GO:0043024; F:ribosomal small subunit binding; IPI:UniProtKB; . GO GO:0003723; F:RNA binding; IDA:UniProtKB; . GO GO:0000977; F:RNA polymerase II regulatory region sequence-specific DNA binding; IEA:Ensembl; . GO GO:0003697; F:single-stranded DNA binding; IEA:Ensembl; . GO GO:0035690; P:cellular response to drug; IEA:Ensembl; . GO GO:0071398; P:cellular response to fatty acid; IEA:Ensembl; . GO GO:0071333; P:cellular response to glucose stimulus; IEA:Ensembl; . GO GO:0006241; P:CTP biosynthetic process; IEA:InterPro; . GO GO:0006897; P:endocytosis; IEA:UniProtKB-KW; . GO GO:0006183; P:GTP biosynthetic process; IEA:InterPro; . GO GO:0021766; P:hippocampus development; IEA:Ensembl; . GO GO:0007595; P:lactation; IEA:Ensembl; . GO GO:0008285; P:negative regulation of cell proliferation; TAS:UniProtKB; . GO GO:0010629; P:negative regulation of gene expression; IEA:Ensembl; . GO GO:0002762; P:negative regulation of myeloid leukocyte differentiation; IEA:Ensembl; . GO GO:0015949; P:nucleobase-containing small molecule interconversion; TAS:Reactome; . GO GO:0043388; P:positive regulation of DNA binding; IDA:UniProtKB; . GO GO:0050679; P:positive regulation of epithelial cell proliferation; IMP:HGNC; . GO GO:0010976; P:positive regulation of neuron projection development; IEA:Ensembl; . GO GO:0042981; P:regulation of apoptotic process; TAS:UniProtKB; . GO GO:0014075; P:response to amine; IEA:Ensembl; . GO GO:0051591; P:response to cAMP; IEA:Ensembl; . GO GO:0033574; P:response to testosterone; IEA:Ensembl; . GO GO:0006228; P:UTP biosynthetic process; IEA:InterPro; . HAMAP MF_00451; NDP_kinase; 1; . InterPro IPR001564; Nucleoside_diP_kinase; . InterPro IPR023005; Nucleoside_diP_kinase_AS; . Pfam PF00334; NDK; 1; . PRINTS PR01243; NUCDPKINASE; . SMART SM00562; NDK; 1; . PROSITE PS00469; NDP_KINASES; 1; .

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